GPAT 2010 Paper

GPAT 2010

Q.l    The vitamin essential in tissue culture medium is

        (A)  Pyridoxine       (B)   Thiamine (C)    Nicotinic acid   (D)   Inositol

        Ans.  B

        Q.2     Gingkgo biloba is used for its

        (A)  Expectorant activity                            (B)  Lipid lowering activity

        (C)  PAF antagonistic activity                       (D)Antidepressant activity

         Ans. C

        Q.3     The amount of barbaloin present in Aloe vera is

        (A)  <1%                 (B)   3.5-4%              (c) 1-1.5%                 (D)  2-2.5%

        Ans. B

        Q.4     Sildenafil is used for treatment of one of the following disorders :

        (A)  Systolic hypertension                           (B)   Unstable angina

        (C)  Pulmonary hypertension                          (D)   Hypertension due to

        eclampsia

        Ans. C

Q.5     Cardiac glycosides have the following configuration in the aglycone part of

        the steroid nucleus :

        (A)  5a, 1 4 a -                (B)5a, 14β-          (C)   5β, 1 4 a -      (D)  5β,14β-

        Ans. D

        Q.6     Quassia wood is adulterated with

        (A)  Brucea antidysentrica                           (B)   Cassia angustifoila

        (C)  Cinnamomum zeylanicum                           (D)   Cephaelis ipecacuanaha

        Ans. B

        Q.7     Eugenol is present in

        (A)  Fennel               (B)  Tulsi         (C)   Cardamom           (D)  Coriander

Ans. B

        Q.8    Which one of the following drugs is prescribed for the treatment of

        Philadelphia chromosome positive patients with Chronic myeloid Leukemia?

        (A)  Pentostatin                                    (B)  Methotrexate

        (C) Imatinib                                        (D)  L-Asparaginase

        Ans. C

        Q.9    Which  of the  following  monoclonal  antibodies  is  prescribed  for  patients

        with non-Hodgkin's Lymphoma?

        (A)  Infliximab      (B)  Abciximab  (C)    Gemtuzumab      (D)  Rituximab

        Ans. D

         Q.10   Identify the drug which is NOT used in the treatment of malaria caused by

       Plasmodium falciparum :

        (A.)  Artemisinin     (B)  Primaquine              (C)  Quinine            (D)

        Mefloquine

        Ans. B

        Q.ll  Which one of the following drugs does NOT act through G-Protein coupled

        receptors?

        (A)  Epinephrine     (B)  Insulin                  (C)  Dopamine        (D)  TSH

Ans. B

         Q.12   Which one of the following drugs is most effective in preventing transmission

        of HIV virus from the mother to the foetus?

        (A)  Lamivudine     (B)   Zidovudine               (C)  Indinavir          (D)

        Ribavirin

        Ans.  B

         Q.13   Improvement of memory in Alzheimer's disease is brought about by drugs

        which increase transmission in

        (A)  cholinergic receptors                         (B)  dopaminergic receptors

        (C) GABAergic receptors                            (D)   adrenergic receptors

Ans. A

       Q.14    Which of the following non-opioid analgesics is a prodrug?

       (A)   Piroxicam        (B)  Celecoxib        (C)Nabumetone      (D)   Ketorolac

       Ans. C

       Q.15    Which one of the following drugs is NOT a typical anti-psychotic agent?

       (A)   Chlorpromazine                               (B)  Haloperidol

       (C)   Risperidone                                  (D)  Flupentixol

        Ans.  C

       Q.16    Which one of the followings is a plasminogen activator?

       (A) Tranexamic acid                                (B)  Streptokinase

       (C)   Aminocaproic acid                            (D)  None of the above

       Ans. B

       Q.17    Myasthenia gravis is diagnosed with improved neuromuscular function by

       using

        (A)  Donepezil          (B)  Edrophonium        (C)  Atropine (D)   Pancuronium

       Ans. B

Q.18    Which one of the following drugs specifically inhibits calcineurin in the

       activated T lymphocytes?

       (A)   Daclizumab     (B)  Prednisone (C)  Sirolimus                       (D)

       Tacrolimus

       Ans.  D

       Q.19    The chemical behaviour of morphine alkaloid is

       (A)   acidic  (B)Basic   (C)  neutral (D)  amphoteric

        Ans. B

       Q.20    At physiological pH the following compound would be MOSTLY in the

(A)  cationic form                                  (B)  unionized form

        (C)  zwitterionic form                              (D)  anionic form

        Ans. B

        Q.21    Which one of the followings is used as a mood stabilizer for bipolar disorder

        and also in certain epileptic convulsions?

        (A)  Phenytoin                                     (B)  Lithium

        (C)  Sodium valproate                               (D)  Fluoxetine

        Ans. C

        Q.22   An isosteric replacement for carboxylic acid group is

        (A)  pyrrole             (B)  isoxazole            (C)  phenol              (D)

        Tetrazole

Ans.-D

        Q.23   The given antibiotic is an example of ansamycins :

        (A)  Roxythromycin (B)     Adriamycin (C)    Aureomycin       (D)   Rifamycin

        Ans. D

        Q.24   For glyburide, all of the following metabolic reactions are logical EXCEPT

        (A)   O-demethylation                         (B)  aromatic oxidation

        (C)  benzylic hydroxylation                   (D)  amide hydrolysis

        Ans. B

        Q.25   The   effects  observed  following  systemic  administration  of  levodopa  in  the treatment   of  Parkinsonism   have   been  attributed  to  its  catabolism  to  dopamine. Carbidopa, can markedly increase the proportion of levodopa that crosses the blood-brain barrier by

(A)     increasing penetration of levodopa through BBB by complexation with it

        (B)   decreasing peripheral metabolism of levodopa

        (C)   decreasing metabolism of levodopa in the CNS

        (D)   decreasing clearance of levodopa from the CNS

        Ans. B

        Q.26    Ethambutol molecule has

        (A)  two chiral centers and 3 stereoisomers

        (B)  two chiral centers and 4 stereoisomers

        (C)   two chiral centers and 2 stereoisomers

        (D)   one chiral center and 2 stereoisomers

        Ans. B

        Q.27    A compound will be sensitive towards IR radiation only when one of the

        following properties undergo transition on

        (A)  Polarizability                                  (B)  Dielectric constant

        (C)  Dipole moment                                   (D)  Refractivity

        Ans.  C

        Q.28    X-ray crystallographic analysis of an optically active compound determines its

        (A)  Optical rotatory dispersive power               (B)  Absolute configuration

        (C)  Relative configuration                          (D)   Optical purity

Ans. B

        Q.29    Which one of the following statements is WRONG?

        (A)  A singlet or triplet state may result when one of the electrons from the HOMO is  excited to higher energy levels

        (B)   In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the electron in the ground state orbital

        (C)   Triplet excited state is more stable than the singlet excited state

        (D) When the electron from the singlet excited state returns to ground state, the molecule always shows fluorescence phenomenon

        Ans. C

  Q.30    Aminotransferases usually require the following for their activity :

(A)  Niacinamide           (B)Vitamin B12   (C)  Pyridoxal phosphate  (D)   Thiamine

   Ans. C