GPAT 2010
Q.l The vitamin essential in tissue culture medium is
(A) Pyridoxine (B) Thiamine (C) Nicotinic acid (D) Inositol
Ans. B
Q.2 Gingkgo biloba is used for its
(A) Expectorant activity (B) Lipid lowering activity
(C) PAF antagonistic activity (D)Antidepressant activity
Ans. C
Q.3 The amount of barbaloin present in Aloe vera is
(A) <1% (B) 3.5-4% (c) 1-1.5% (D) 2-2.5%
Ans. B
Q.4 Sildenafil is used for treatment of one of the following disorders :
(A) Systolic hypertension (B) Unstable angina
(C) Pulmonary hypertension (D) Hypertension due to
eclampsia
Ans. C
Q.5 Cardiac glycosides have the following configuration in the aglycone part of
the steroid nucleus :
(A) 5a, 1 4 a - (B)5a, 14β- (C) 5β, 1 4 a - (D) 5β,14β-
Ans. D
Q.6 Quassia wood is adulterated with
(A) Brucea antidysentrica (B) Cassia angustifoila
(C) Cinnamomum zeylanicum (D) Cephaelis ipecacuanaha
Ans. B
Q.7 Eugenol is present in
(A) Fennel (B) Tulsi (C) Cardamom (D) Coriander
Ans. B
Q.8 Which one of the following drugs is prescribed for the treatment of
Philadelphia chromosome positive patients with Chronic myeloid Leukemia?
(A) Pentostatin (B) Methotrexate
(C) Imatinib (D) L-Asparaginase
Ans. C
Q.9 Which of the following monoclonal antibodies is prescribed for patients
with non-Hodgkin's Lymphoma?
(A) Infliximab (B) Abciximab (C) Gemtuzumab (D) Rituximab
Ans. D
Q.10 Identify the drug which is NOT used in the treatment of malaria caused by
Plasmodium falciparum :
(A.) Artemisinin (B) Primaquine (C) Quinine (D)
Mefloquine
Ans. B
Q.ll Which one of the following drugs does NOT act through G-Protein coupled
receptors?
(A) Epinephrine (B) Insulin (C) Dopamine (D) TSH
Ans. B
Q.12 Which one of the following drugs is most effective in preventing transmission
of HIV virus from the mother to the foetus?
(A) Lamivudine (B) Zidovudine (C) Indinavir (D)
Ribavirin
Ans. B
Q.13 Improvement of memory in Alzheimer's disease is brought about by drugs
which increase transmission in
(A) cholinergic receptors (B) dopaminergic receptors
(C) GABAergic receptors (D) adrenergic receptors
Ans. A
Q.14 Which of the following non-opioid analgesics is a prodrug?
(A) Piroxicam (B) Celecoxib (C)Nabumetone (D) Ketorolac
Ans. C
Q.15 Which one of the following drugs is NOT a typical anti-psychotic agent?
(A) Chlorpromazine (B) Haloperidol
(C) Risperidone (D) Flupentixol
Ans. C
Q.16 Which one of the followings is a plasminogen activator?
(A) Tranexamic acid (B) Streptokinase
(C) Aminocaproic acid (D) None of the above
Ans. B
Q.17 Myasthenia gravis is diagnosed with improved neuromuscular function by
using
(A) Donepezil (B) Edrophonium (C) Atropine (D) Pancuronium
Ans. B
Q.18 Which one of the following drugs specifically inhibits calcineurin in the
activated T lymphocytes?
(A) Daclizumab (B) Prednisone (C) Sirolimus (D)
Tacrolimus
Ans. D
Q.19 The chemical behaviour of morphine alkaloid is
(A) acidic (B)Basic (C) neutral (D) amphoteric
Ans. B
Q.20 At physiological pH the following compound would be MOSTLY in the
(A) cationic form (B) unionized form
(C) zwitterionic form (D) anionic form
Ans. B
Q.21 Which one of the followings is used as a mood stabilizer for bipolar disorder
and also in certain epileptic convulsions?
(A) Phenytoin (B) Lithium
(C) Sodium valproate (D) Fluoxetine
Ans. C
Q.22 An isosteric replacement for carboxylic acid group is
(A) pyrrole (B) isoxazole (C) phenol (D)
Tetrazole
Ans.-D
Q.23 The given antibiotic is an example of ansamycins :
(A) Roxythromycin (B) Adriamycin (C) Aureomycin (D) Rifamycin
Ans. D
Q.24 For glyburide, all of the following metabolic reactions are logical EXCEPT
(A) O-demethylation (B) aromatic oxidation
(C) benzylic hydroxylation (D) amide hydrolysis
Ans. B
Q.25 The effects observed following systemic administration of levodopa in the treatment of Parkinsonism have been attributed to its catabolism to dopamine. Carbidopa, can markedly increase the proportion of levodopa that crosses the blood-brain barrier by
(A) increasing penetration of levodopa through BBB by complexation with it
(B) decreasing peripheral metabolism of levodopa
(C) decreasing metabolism of levodopa in the CNS
(D) decreasing clearance of levodopa from the CNS
Ans. B
Q.26 Ethambutol molecule has
(A) two chiral centers and 3 stereoisomers
(B) two chiral centers and 4 stereoisomers
(C) two chiral centers and 2 stereoisomers
(D) one chiral center and 2 stereoisomers
Ans. B
Q.27 A compound will be sensitive towards IR radiation only when one of the
following properties undergo transition on
(A) Polarizability (B) Dielectric constant
(C) Dipole moment (D) Refractivity
Ans. C
Q.28 X-ray crystallographic analysis of an optically active compound determines its
(A) Optical rotatory dispersive power (B) Absolute configuration
(C) Relative configuration (D) Optical purity
Ans. B
Q.29 Which one of the following statements is WRONG?
(A) A singlet or triplet state may result when one of the electrons from the HOMO is excited to higher energy levels
(B) In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the electron in the ground state orbital
(C) Triplet excited state is more stable than the singlet excited state
(D) When the electron from the singlet excited state returns to ground state, the molecule always shows fluorescence phenomenon
Ans. C
Q.30 Aminotransferases usually require the following for their activity :
(A) Niacinamide (B)Vitamin B12 (C) Pyridoxal phosphate (D) Thiamine
Ans. C
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